Isolation and characterization of cholecystokinin-58 (CCK-58) from porcine brain
نویسندگان
چکیده
منابع مشابه
CCK-58 is the only detectable endocrine form of cholecystokinin in rat.
CCK-58 differs from CCK-8 in patterns of expression of pancreatic secretion of fluid and amylase and gallbladder contraction. These differences have physiological relevance only if CCK-58 release is stimulated by nutrients entering the intestine and if CCK-58 circulates in sizeable amounts. In this study, we report that when radiolabeled CCK-58 is added to rat blood and plasma is formed, there ...
متن کاملDifferential bile-pancreatic secretory effects of CCK-58 and CCK-8.
In this work, we 1) synthesized rat CCK-58, 2) determined the amounts and forms of rat CCK in whole blood after stimulation of its release by casein, 3) determined the potency of CCK-8 and CCK-58 peptides to displace labeled CCK-8 from CCK(A) and CCK(B) receptors transfected into Chinese hamster ovary (CHO) cells, and 4) examined the biological actions of CCK-8 and rat CCK-58 in an anesthetized...
متن کاملEffects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation.
Cholecystokinin, like many peptide hormones, is present as multiple molecular forms. CCK-58 has been identified as the dominant form in the circulation, whereas most of the studies of CCK-receptor interactions have been performed with CCK-8. Despite both sharing the pharmacophoric region of CCK, representing its carboxy terminal heptapeptide amide, studies in vivo have demonstrated biological d...
متن کاملCCK - 8 and CCK - 58 differ in their effects on nocturnal solid meal 1 pattern in undisturbed rats
26 Various molecular forms of cholecystokinin (CCK) reduce food intake in rats. Although CCK-8 is the 27 most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We 28 investigated the dark phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum 29 fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (...
متن کاملCCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats.
Various molecular forms of CCK reduce food intake in rats. Although CCK-8 is the most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We investigated the dark-phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum-fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (0.6, 1.8, and 5.2 nmol/kg), or...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1984
ISSN: 0014-5793
DOI: 10.1016/0014-5793(84)81175-8